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Year Number of Results
2009 1
2010 1
2011 1
2013 3
2014 1
2015 3
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2019 1
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2021 3
2022 1
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16 results

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Page 1
Sp1-induced upregulation of the long noncoding RNA TINCR inhibits cell migration and invasion by regulating miR-107/miR-1286 in lung adenocarcinoma.
Gao YW, Ma F, Xie YC, Ding MG, Luo LH, Jiang S, Rao L, Liu XL. Gao YW, et al. Am J Transl Res. 2019 Aug 15;11(8):4761-4775. eCollection 2019. Am J Transl Res. 2019. PMID: 31497197 Free PMC article.
However, little is known about the function and mechanism of TINCR in lung adenocarcinoma (LUAD). Here, we aimed to analyze expression of TINCR and elucidate its mechanistic involvement in the progression of LUAD. ...Results indicated TINCR could constrain the expression o …
However, little is known about the function and mechanism of TINCR in lung adenocarcinoma (LUAD). Here, we aimed to analyze expressio …
Arecoline promotes proliferation and migration of human HepG2 cells through activation of the PI3K/AKT/mTOR pathway.
Xie H, Jing R, Liao X, Chen H, Xie X, Dai H, Pan L. Xie H, et al. Hereditas. 2022 Jul 14;159(1):29. doi: 10.1186/s41065-022-00241-0. Hereditas. 2022. PMID: 35836300 Free PMC article.
These genes are involved in the PI3K-AKT pathway. CDK1, CCND1, RAF1, CDKN1B and BTRC were defined as the top 5 hub target genes, and patients with high expression of CDK1 showed poor prognosis. ...
These genes are involved in the PI3K-AKT pathway. CDK1, CCND1, RAF1, CDKN1B and BTRC were defined as the top 5 hub target genes, and …
Progesterone receptor membrane component 1 leads to erlotinib resistance, initiating crosstalk of Wnt/beta-catenin and NF-kappaB pathways, in lung adenocarcinoma cells.
Lin Y, Higashisaka K, Shintani T, Maki A, Hanamuro S, Haga Y, Maeda S, Tsujino H, Nagano K, Fujio Y, Tsutsumi Y. Lin Y, et al. Sci Rep. 2020 Mar 16;10(1):4748. doi: 10.1038/s41598-020-61727-3. Sci Rep. 2020. PMID: 32179851 Free PMC article.
Furthermore, AG-205 reduced the expression of beta-TrCP (also known as BTRC), suggesting that PGRMC1 enhanced the crosstalk between NF-kappaB (also known as NFKB) signaling and Wnt/beta-catenin signaling in an erlotinib-dependent manner. ...
Furthermore, AG-205 reduced the expression of beta-TrCP (also known as BTRC), suggesting that PGRMC1 enhanced the crosstalk between N …
Establishment of Sunitinib-Resistant Xenograft Model of Renal Cell Carcinoma and the Identification of Drug-Resistant Hub Genes and Pathways.
Xie Y, Shangguan W, Chen Z, Zheng Z, Chen Y, Zhong Q, Zhang Y, Yang J, Zhu D, Xie W. Xie Y, et al. Drug Des Devel Ther. 2021 Dec 16;15:5061-5074. doi: 10.2147/DDDT.S343718. eCollection 2021. Drug Des Devel Ther. 2021. PMID: 34938069 Free PMC article.
Then, comprehensive expression analysis of the hub genes, and finally, the genes BTRC and TRIM32 were identified, which were consistent in all observations. ...
Then, comprehensive expression analysis of the hub genes, and finally, the genes BTRC and TRIM32 were identified, which were consiste …
FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization.
Su JL, Cheng X, Yamaguchi H, Chang YW, Hou CF, Lee DF, Ko HW, Hua KT, Wang YN, Hsiao M, Chen PB, Hsu JM, Bast RC Jr, Hortobagyi GN, Hung MC. Su JL, et al. Cancer Res. 2011 Nov 1;71(21):6878-87. doi: 10.1158/0008-5472.CAN-11-0295. Epub 2011 Sep 12. Cancer Res. 2011. PMID: 21911455 Free PMC article.
Long noncoding RNA ASB16-AS1 inhibits adrenocortical carcinoma cell growth by promoting ubiquitination of RNA-binding protein HuR.
Long B, Yang X, Xu X, Li X, Xu X, Zhang X, Zhang S. Long B, et al. Cell Death Dis. 2020 Nov 20;11(11):995. doi: 10.1038/s41419-020-03205-2. Cell Death Dis. 2020. PMID: 33219221 Free PMC article.
We then found that inhibition of ASB16-AS1 attenuates the binding of ubiquitin E3 ligase BTRC to HuR and subsequently inhibits HuR protein unbiquitination and degradation. BTRC knock-down could reverse the effect of AB16-AS1 on HuR, CDK6, and IGF1R levels. ...
We then found that inhibition of ASB16-AS1 attenuates the binding of ubiquitin E3 ligase BTRC to HuR and subsequently inhibits HuR pr …
Mutual interaction between YAP and CREB promotes tumorigenesis in liver cancer.
Wang J, Ma L, Weng W, Qiao Y, Zhang Y, He J, Wang H, Xiao W, Li L, Chu Q, Pan Q, Yu Y, Sun F. Wang J, et al. Hepatology. 2013 Sep;58(3):1011-20. doi: 10.1002/hep.26420. Epub 2013 Jul 16. Hepatology. 2013. PMID: 23532963
By contrast, YAP promotes protein stabilization of CREB through interaction with mitogen-activated protein kinase 14 (MAPK14/p38) and beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC). Gain-of-function and loss-of-function studies demonstrated that phosp …
By contrast, YAP promotes protein stabilization of CREB through interaction with mitogen-activated protein kinase 14 (MAPK14/p38) and beta-t …
MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer.
Li L, Wang J, Zhang Y, Zhang Y, Ma L, Weng W, Qiao Y, Xiao W, Wang H, Yu W, Pan Q, He Y, Sun F. Li L, et al. FEBS Lett. 2013 Dec 11;587(24):3921-7. doi: 10.1016/j.febslet.2013.10.042. Epub 2013 Nov 7. FEBS Lett. 2013. PMID: 24211253 Free article.
Mechanistically, inhibition of MEK1 by both PD98059 and U0126 as well as RNAi reduces beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC), which acts as a potential endogenous YAP protector....
Mechanistically, inhibition of MEK1 by both PD98059 and U0126 as well as RNAi reduces beta-transducin repeat containing E3 ubiquitin protein …
Effect of TP53 16-bp and β-TrCP 9-bp INS/DEL polymorphisms in relation to risk of breast cancer.
Eskandari-Nasab E, Hashemi M, Amininia S, Ebrahimi M, Rezaei M, Hashemi SM. Eskandari-Nasab E, et al. Gene. 2015 Sep 1;568(2):181-5. doi: 10.1016/j.gene.2015.05.048. Epub 2015 May 21. Gene. 2015. PMID: 26003292
P53 as a tumor suppressor and an apoptosis modulator, is the regulator of the cell cycle and apoptosis, and contributes to mammary gland development and breast cancer (BC) progression. BTRC gene (Homo sapiens beta-transducing repeat containing E3 ubiquitin protein ligase) …
P53 as a tumor suppressor and an apoptosis modulator, is the regulator of the cell cycle and apoptosis, and contributes to mammary gland dev …
16 results